The Protein Function Discovery Facility (PFD) was established at Queen's
University in 2001 through grants from the Canadian Foundation for Innovation
(CFI) and the Ontario Innovation Trust (OIT).
The suite of instrumentation housed in the PFD Facility has enabled a multi-
directional approach to the characterization of biomolecules and their
interactions: Isothermal titrating calorimetry, differential scanning
calorimetry, circular dichroism spectrophotometry, analytical
ultracentrifugation, Biacore (surface plasmon resonance), fluorimetry (standard
and anisotropy), mass spectrometry (MALD-TOF and q-TOF), and SEC-MALS. While the
principle emphasis of PFD has been answering research questions involving
protein-mediated biological systems, we have also enjoyed success in adapting
these techniques to answer specific questions for a variety of projects
involving inorganic chemistry and chemical engineering.
Since its inception, PFD has provided research support to nearly 90 research
laboratories in multiple Queen's departments, in addition to laboratories from
external academic institutions and private industry. Our work has contributed
high-quality results to a wide variety of research projects, supported over two
hundred publications and student theses, and helped reinforce foundations for
numerous successful research grant applications.
In addition to its direct contributions to research, the PFD facility has also
functioned to provide individual or small-group training to graduate and
undergraduate students concerning the theoretical and practical considerations
of biophysical characterization experimentation. This goal is often accomplished
in concert with tailoring the use of these techniques to support individual
student research projects.
For enquiries regarding the applicability of PFD equipment to specific research
projects and fee-for-service rates, please contact Kim Munro:
Phone: (613) 533-6000, ext.78369